Avian influenza is a virulent infection caused by influenza a virus, known as H7N9, H5N1, etc. H and N are glycoproteins that make up the two components of the influenza a virus, they can easily mutate into different types of H and N, thus forming different viruses, and it is extremely difficult to control.
An avian influenza virus antibody ( an All human sources neutralize antibodies) against the H5N1 avian influenza virus was produced through cloning genes from human lymphocytes and reproducing them by the Nanjing Medical University cooperated with the Jiangsu Provincial Center for Disease Control. It can be made into drugs can "seal" the virus in the patient to prevent and treat human infection with the H5N1 avian influenza virus. The result has been obtained the national invention patent.
H is hemagglutinin (HA), N is neuraminidase (NA). Professor Feng Zhenqing, a professor at nanjing medical university's key laboratory for antibody technology, said that HA is like a "key" in the hands of a virus that opens and invades the cells of people and animals. Recent research has found that there are few areas of change in the "key" protein, which offers hope for the development of a wide range of antibodies. Let the avian influenza virus antibody combine with these areas, just as a "key" is sealed, it can prevent the virus from exerting its power. Because the "key" is on the surface of the virus, it is the perfect target for an antibody drug.
With the "target", where does the weapon come from?"Zhenqing Feng said, “The lymphocytes are responsible for "guarding" in the body, which can remember the characteristics of the "criminal" virus in the vaccine, and produce a small number of "weapons" antibodies that are specifically designed to deal with such "criminals".” However, when the virus infects the body, "weapon" is not enough. We have to use artificial antibodies to make antibodies.
The team focus on the strongest pathogenicity of H5N1 virus. By cloning the genome of the antibody produced by the lymphocytes, the HA protein of the H5N1 strain of the human species was artificially synthesized and one avian influenza virus antibody was finally detected, which can broadly neutralize Various animal sources of the virus.
This kind of avian influenza virus antibody (GLORY SCIENCE CO., LTD) can be produced in mass production and using technologies such as genetic engineering. Enough antibodies can be prepared into drugs, injected into the body, neutralizing the virus, and treating the disease. Due to its characteristics of "full human resources", there will not be an exclusive reaction in the use of the drug. It will be safer and more effective.