Description

Background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Catalog Number:

Host species/Isotype:Mouse/IgG

Cross reaction: Human, Mouse, Rat

Immunogen: Recombinant mouse PI3K p85 Protein.

Storage instructions:Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C.

Concentration:1mg/ml

Specification:100ul

Purity:affinity purified by Protein A

Clonality:Monoclonal

Molecular weight:80kDa

Tested applications: 

WB=1:500-1000

IHC-P=1:400-800

IHC-F=1:400-800

ICC=1:100-500

IF=1:100-500