ZNT8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.
Species reactivity: Human, Mouse, Rat, Dog, Pig, Sheep,
Immunogen: KLH conjugated synthetic peptide derived from human ZNT8:101-200/369
Storage instructions:Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Purity: affinity purified by Protein A
Molecular weight : 41kDa
Tested applications: WB=1:500-2000 ,ELISA=1:500-1000 ;not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.