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Sigma-1 Receptor

What role does Sigma-1 Receptor play in our body? The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein resides specifically at the interface between ER and mitochondria, called the MAM.The Sig-1R has been reported to be involved with certain CNS diseases.
Sig-1R may be associated with amyotrophic lateral sclerosis.Deletion of Sig-1R function disrupts ER-mitochondrial contact, leading to a decrease in Ca2+ signaling, leading to amyotrophic lateral sclerosis in animals. The close proximity of Sig-1R to the muscarinic acetylcholine receptor on the plasma membrane may also be associated with the disease.Sig-1R-IP3R-VDAC-linked ER-mitochondrial cross-reaction plays an important role in the pathogenesis of Alzheimer’s disease.
Sig-1R maintains the structural integrity of the MAM. The Sig-1R-IP3R-VDAC-linked ER-mitochondrial cross-reaction plays an important role in the pathogenesis of Alzheimer’s disease. Insig can affect the synthesis of cholesterol, and the interaction of Sig-1R-Insig may be related to the disease.
Sig-1R may be an endogenous pain regulator in the CNS. Sig-1R is co-immunoprecipitated with MOR in HEK cells, and Sig-1R is also co-immunoprecipitated with NMDA receptor subunits GluN2 and CB1R.NMDA receptor subunits GluN2 and CB1R are involved in the perception of pain.