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What role does histamine play in acute inflammation?

What role does histamine play in acute inflammation?

Histamine is to our body what bouncers are to a club. This is the easiest way to understand the role and function of histamine in our body. It is an active chemical of our immunity system and fights any foreign particle that enters your body. In short, each time you ask what role does histamine play? Know it’s the role of bouncers protecting human body.

Histamine is a type of autacoids that is similar to local hormones acting at sites of synthesis. It is secreted as a part of the body’s immunity system and causes several inflammatory and allergic actions as a reaction to invasion of foreign particles. Most of our body’s histamine production occurs in the granules of mast cells and white blood cells such as eosinophils and basophils. These mast cells and basophils are mostly concentrated in areas where maximum injuries occur, like nose, mouth, feet and blood vessel.

How does histamine work? Whenever your body senses any foreign body or allergen such as pollen or dust particle has entered the blood stream, it sends signals to the brain to release histamine. Histamine that is stored in mast cells, in turn rushes to the site of allergen and boosts the blood flow in that area causing inflammation. This kind of role does histamine play in body inflammation.

When histamine arrives at the affected body part, it causes the small blood vessels to dilate and widen. This is a defense mechanism of your body that causes swelling, inflammation or itchiness. This is important to rouse the attention of other body chemicals in initiating their process of healing. By allowing the more blood to flow into the site of irritation, the role does histamine play is to offer faster recovery. The mediation of histamine is activated through the H1 receptor. H4 receptors are also active agents in treating inflammatory and allergic conditions.


Histamine produces many actions of inflammation like vasodilation, increased vascular permeability, and edema. All of these are kinds of swelling that occurs due to dilated blood vessels. After the inflammation has begun, either of two kinds of action begins: Healing and repair which means - The body starts proliferate regeneration of damaged tissues. The time taken depends upon the structure and location of tissue. Here, the role does histamine play is to initiate the process of regeneration in body.


The act of pus formation is called suppuration. This happens when the foreign allergen is hard to eliminate. Pus consists of dead bacteria, cellular debris and fluid leaked from dilated blood vessels. Some cases of suppuration require surgical intervention, while some ejaculate by themselves. Although histamine occurs naturally in human cells, it is also used in antibiotics to treat allergic conditions. Thus, it calls for a huge demand for medical and laboratory researchers to produce drugs and medicines. This is injected into the body to create anti-histamine to cure acute allergic conditions.

Histamine is a vasoactive amine that stimulates acute inflammatory reactions. Apart from, other role does histamine play like cardiovascular effect, gastric secretion, smooth muscle effects, itching, sneezing and production of nasal mucosa.