“We have started to enter the orthopaedic revolution, and we could promote regeneration by combining engineering and Biological approach, which will be the future of medicine.” Dan Gazit said, the director of the Institute for Bone Regeneration, Stem Cell Therapy and Cedars-Sinai Regenerative Medicine.
More than 2 million bone transplants were carried out due to the serious bone damage caused by traffic accidents, wars or removal of tumors all each year in the world. However, sometimes, such damage may make the gap inside the damaged bone tissue too large to bridge. As the lead researcher and co-senior author of the study, Gazit said "Unfortunately, bone transplants have drawbacks, because it's difficult to meet the high demand for bone repair.
One problem is that healthy bones aren't always available for repairing. Removing bone from the pelvis for implantation can result in prolonged pain and hospitalization, expensive prolonged. In addition, transplants from donors may not be fully integrated or grown, leading to repair failure.
Fortunately, new technology developed by cedars-sinai can provide a very effective alternative to bone transplantation. In their experiment, the researchers constructed a collagen matrix, a protein that was used to build bones, and implant it in the gaps between the broken bones of the experimental animals. The matrix was able to attract the stem cell of the damaged bones to the bone damage gap in two weeks.
To start the bone repair process, the team used the cells' ultrasound pulses and microvesicles to promote bone induced gene delivery to stem cells directly. Eight weeks after surgery, the broken bone gap of all the experimental animals was cured. Studies have shown that newborn bones are as strong as surgical bone grafts. “The study was the first to show that ultrasound mediated genes are delivered to the animals' own stem cells can be used to treat non-healing bone effectively. It solves a major orthopedic problem and provides new possibilities for clinical transfer." said of Dr. Gadi pilie, an assistant professor of surgery at cedars-sinai.